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11.24.2019

After the TREAD Act was mandated in 2007, all vehicles manufactured in the United States beginning in 2008, must be installed with direct or indirect TPMS systems.
The Mercedes-Benz E-Class is installed with a direct TPMS system, which means there are TPMS sensors in the wheel. Direct TPMS has TPMS sensors installed in the wheel; if one or more tires indicate low tire pressure, the TPMS sensors will transfer the information to the vehicle’s ECU. An indicator light (low-line TPMS system) or each tire pressure will show on the dash (high-line TPMS system).
A TPMS relearn is recommended after a sensor replacement or tire rotation. When services are performed, such as a tire change or TPMS sensor replacement, in one or more tires of a Mercedes-Benz E-Class, a TPMS relearn must be performed to transfer the sensor information to the vehicle’s ECU.

https://youtu.be/Y3Okke-GCpI
While the video shows a Mercedes-Benz S-Class, the same procedure will work on E-Class vehicles
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